The Gene - An Intimate History
The Gene is the story of one of the most powerful and dangerous ideas in our history, from bestselling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a 'unit of heredity'. It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds - from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history - the story of Mukherjee's own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to "read" and "write" the human genome - unleashing the potential to change the fates and identities of our children. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity - and a vision of both humanity's past and future.
The Gene is the story of one of the most powerful and dangerous ideas in our history, from bestselling, prize-winning author Siddhartha Mukherjee.
Shortlisted for Royal Society Insight Investment Science Book Prize 2016.
"This is perhaps the greatest detective story ever told - a millennia-long search, led by a thousand explorers, from Aristotle to Mendel to Francis Collins, for the question marks at the center of every living cell. Like The Emperor of All Maladies, The Gene is prodigious, sweeping, and ultimately transcendent. If you're interested in what it means to be human, today and in the tomorrows to come, you must read this book" -- Anthony Doerr, Pulitzer Prize-winning author of All the Light We Cannot See "A magnificent synthesis of the science of life, and forces all to confront the essence of that science as well as the ethical and philosophical challenges to our conception of what constitutes being human" -- Paul Berg, winner of the Nobel Prize in Chemistry "Weaving the history of his family's struggle with mental illness into the science bit, this promises to be another mesmerising book that humanises science" Independent
Siddhartha Mukherjee is a cancer physician and researcher, a stem cell biologist and a cancer geneticist. He is the author of The Laws of Medicine and The Emperor of All Maladies: A Biography of Cancer, which won the 2011 Pulitzer Prize in general nonfiction and the Guardian First Book Award. Mukherjee is an assistant professor of medicine at Columbia University. A Rhodes Scholar, he graduated from Stanford University, University of Oxford, and Harvard Medical School. His laboratory has identified genes that regulate stem cells, and his team is internationally recognized for its discovery of skeletal stem cells and genetic alterations in blood cancers. He has published work in Nature, Cell, Neuron, The New England Journal of Medicine, the New York Times and several other magazine and journals. He lives with his family in New York City.